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Endocrine Abstracts

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ea0086ja3 | Society for Endocrinology Journal Award – Endocrine-Related Cancer | SFEBES2022

Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma

Eckardt Luise , Prange-Barczynska Maria , Hodson Emma J , Fielding James W , Cheng Xiaotong , Lima Joanna D C C , Kurlekar Samvid , Douglas Gillian , Ratcliffe Peter J , Bishop Tammie

Endocrine-Related Cancer, 2021, 28(12): 757-772 (DOI: https://doi.org/10.1530/ERC-21-0211)...
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ea0034oc5.1 | Pituitary | SFEBES2014

Increased frequency and earlier onset of pituitary tumours in mice deleted for a multiple endocrine neoplasia type 1 allele and null for prolyl hydroxylase domain protein 1 (Men1+/−/Phd1−/−)

Stevenson Mark , Piret Sian , Javid Mahsa , Bishop Tammie , Reed Anita , Walls Gerard , Gaynor Katie , Newey Paul , Christie Paul , Nicholls Lynn , Ratcliffe Peter , Thakker Rajesh

Cumulative genetic abnormalities within an oncogenic pathway may contribute to earlier onset or increased aggressiveness of cancers. An example in human and murine cancer is the dysregulation of Wnt signalling by inactivation of the adenomatous polyposis coli (APC) gene that results in accumulation of nuclear β-catenin and earlier onset of renal cell carcinoma, which can be accelerated by p53-deficiency. We therefore investigated the effects of such cumulative genetic abn...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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